Conformational dynamics and phase behavior of lipid vesicles in a precisely controlled extensional flow
نویسندگان
چکیده
منابع مشابه
Conformational dynamics of vesicles.
The transport of ions and molecules through membranes is a key ingredient to many biophysical processes. For example, contemporary attempts for gene therapy require transport of DNA fragments through the cellular and nuclear membranes (1); signaling depends on ionic transport through dynamic pores in membranes (see, for example, ref. 2); efficient drug delivery vehicles based on vesicular ‘‘bag...
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15 صفحه اولPhase transition induced fission in lipid vesicles.
In this work we demonstrate how the first order phase transition in giant unilamellar vesicles (GUVs) can function as a trigger for membrane fission. When driven through their gel-fluid phase transition GUVs exhibit budding or pearl formation. These buds remain connected to the mother vesicle presumably by a small neck. Cooling these vesicles from the fluid phase (T>T(m)) through the phase tran...
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We formulate a coarse-grained molecular-dynamics model of polymer chains in solution that includes hydrodynamic interactions, thermal fluctuations, nonlinear elasticity, and topology-preserving solvent mediated excluded volume interactions. The latter involve a combination of potential forces with explicit geometric detection and tracking of chain entanglements. By solving this model with numer...
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ژورنال
عنوان ژورنال: Soft Matter
سال: 2020
ISSN: 1744-683X,1744-6848
DOI: 10.1039/c9sm02048a